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Maternal TET3 is dispensable for embryonic development but is required for neonatal growth

28 Oct 2015

Abstract excerpt

The development of multicellular organisms is accompanied by reprogramming of the epigenome in specific cells, with the epigenome of most cell types becoming fixed after differentiation. Genome-wide reprogramming of DNA methylation occurs in primordial germ cells and in fertilized eggs during mammalian embryogenesis. The 5-methylcytosine (5mC) content of DNA thus undergoes a marked decrease in the paternal...

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PMID: 26507142
DOI: 10.1038/srep15876

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Maternal TET3 is dispensable for embryonic development but is required for neonatal growthPMID 26507142Read ↗

Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosineSemantic proximity Read ↗

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Genome-wide bisulfite sequencing in zygotes identifies demethylation targets and maps the contribution of TET3 oxidation.Semantic proximity Read ↗

Transcriptional activation of transposable elements in mouse zygotes is independent of Tet3-mediated 5-methylcytosine oxidationSemantic proximity Read ↗

TET1 Catalytic Activity is Required for Reprogramming of Imprinting Control Regions and Patterning of Sperm-Specific Hypomethylated RegionsSemantic proximity Read ↗

Crosstalk between the Methyl-Cytosine Dioxygenase TET3 and the Methyl-CpG-binding protein MECP2 Controls Neuronal MaturationSemantic proximity Read ↗

Mitochondrial genome undergoes de novo DNA methylation that protects mtDNA against oxidative damage during the peri-implantation windowSemantic proximity Read ↗

EHMT2 and SETDB1 protect the maternal pronucleus from 5mC oxidationSemantic proximity Read ↗

Tet1 controls meiosis by regulating meiotic gene expression.Semantic proximity Read ↗

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