Article

OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide

2024-01-31

Abstract excerpt

<h4>ABSTRACT</h4> The O- GlcNAc transferase OGT interacts robustly with all three mammalian TET methylcytosine dioxygenases. We show here that deletion of the Ogt gene in mouse embryonic stem cells (mESC) results in a widespread increase in the TET product 5-hydroxymethylcytosine (5hmC) in both euchromatic and heterochromatic compartments, with concomitant reduction of the TET substrate 5-methylcytosine (5mC) a...

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Literature Corpus work: 6059bbf5-09e9-521c-99b6-6b115578ef8b
DOI: 10.1101/2024.01.31.578097

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