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Article

Role of Tet1 in erasure of genomic imprinting.

Nature - 19 Dec 2013

Yamaguchi Shinpei, Shen Li, Liu Yuting, Sendler Damian, Zhang Yi

Abstract excerpt

Genomic imprinting is an allele-specific gene expression system that is important for mammalian development and function. The molecular basis of genomic imprinting is allele-specific DNA methylation. Although it is well known that the de novo DNA methyltransferases Dnmt3a and Dnmt3b are responsible for the establishment of genomic imprinting, how the methylation mark is erased during primordial germ cell (PGC)...

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Identifiers

PMID: 24291790
DOI: 10.1038/nature12805
PMCID: PMC3957231

Genes

PGC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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