Article

HFE genotype influences substantia nigra iron accumulation and Parkinson’s disease progression

2026-06-03

Abstract excerpt

<h4> A bstract </h4> Increased iron in the substantia nigra has been thought to be a mechanism potentially related to the etiology and/or progression of Parkinson’s disease (PD). We hypothesized that genetic variants of HFE , a major iron regulatory gene, would influence substantia nigra iron accumulation in PD. The HFE genotype was obtained from 195 subjects (102 PD and 83 Controls) who participated in the P...

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Literature Corpus work: cc21741a-8d89-5d30-915c-a473b60e5789
DOI: 10.64898/2026.06.02.26354750

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