Article
Serum iron levels and the risk of Parkinson disease: a Mendelian randomization study.
PLoS medicine - 1 Jan 2013
Pichler Irene, Del Greco M Fabiola, Gögele Martin, Lill Christina M, Bertram Lars, Do Chuong B, Eriksson Nicholas, Foroud Tatiana, Myers Richard H, Nalls Michael, Keller Margaux F, Benyamin Beben, Whitfield John B, Pramstaller Peter P, Hicks Andrew A, Thompson John R, Minelli Cosetta
Abstract excerpt
BACKGROUND: Although levels of iron are known to be increased in the brains of patients with Parkinson disease (PD), epidemiological evidence on a possible effect of iron blood levels on PD risk is inconclusive, with effects reported in opposite directions. Epidemiological studies suffer from problems of confounding and reverse causation, and mendelian randomization (MR) represents an alternative approach to...
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