Article

A mouse model of hemochromatosis-related mutations with brain iron dyshomeostasis exhibits loss of tyrosine hydroxylase expression in dopaminergic neurons and motor control impairment relevant to Parkinson’s disease

2025-05-07

Abstract excerpt

UK Biobank studies show Parkinson’s disease risk is almost doubled in men homozygous for the homeostatic iron regulator gene HFE p.C282Y polymorphism, associated with the common genetic iron disorder hemochromatosis. Whether this relationship is causal or spurious is unknown. We previously reported a novel Hfe -/- xTfr2 mut mouse model of hemochromatosis with elevated brain iron (∼1.5-1.8x). We now show these mi...

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Literature Corpus work: 2dae5898-8c54-59dc-a799-532353e54c74
DOI: 10.1101/2025.05.06.648286

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