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Article

HFE Genotype Restricts the Response to Paraquat in a Mouse Model of Neurotoxicity.

Journal of neurochemistry - 1 May 2018

Nixon Anne M, Meadowcroft Mark D, Neely Elizabeth B, Snyder Amanda M, Purnell Carson J, Wright Justin, Lamendella Regina, Nandar Wint, Huang Xuemei, Connor James R

Abstract excerpt

Parkinson's disease is marked clinically by motor dysfunction and pathologically by dopaminergic cell loss in the substantia nigra and iron accumulation in the substantia nigra. The driver underlying iron accumulation remains unknown and could be genetic or environmental. The HFE protein is critical for the regulation of cellular iron uptake. Mutations within this protein are associated with increased iron...

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Source

Identifiers

PMID: 29315562
DOI: 10.1111/jnc.14299

Genes

HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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HFE Genotype Restricts the Response to Paraquat in a Mouse Model of Neurotoxicity.PMID 29315562Read ↗

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A mouse model of hemochromatosis-related mutations with brain iron dyshomeostasis exhibits loss of tyrosine hydroxylase expression in dopaminergic neurons and motor control impairment relevant to Parkinson’s diseaseSemantic proximity Read ↗

The roles of iron and HFE genotype in neurological diseases.Semantic proximity Read ↗

H63D HFE genotype accelerates disease progression in animal models of amyotrophic lateral sclerosis.Semantic proximity Read ↗

H63D variant of the homeostatic iron regulator (HFE) gene alters α-synuclein expression, aggregation, and toxicity.Semantic proximity Read ↗

Genetic-based, differential susceptibility to paraquat neurotoxicity in mice.Semantic proximity Read ↗

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