Article
Genetic impacts on nigral iron deposition in Parkinson's disease: A preliminary quantitative susceptibility mapping study.
CNS neuroscience & therapeutics - 1 Jul 2023
Wu Jingjing, Guo Tao, Zhou Cheng, Bai Xueqin, Liu Xiaocao, Gu Luyan, Xuan Min, Gu Quanquan, Huang Peiyu, Song Zhe, Zhang Baorong, Xu Xiaojun, Zhang Minming, Guan Xiaojun
Abstract excerpt
BACKGROUND: Dysfunction of iron metabolism, especially in substantia nigra (SN), is widely acknowledged in Parkinson's disease (PD), but the genetic influence on iron deposition remains largely unknown. Thus, in this study, we aimed to investigate potential genetic impacts on iron deposition in PD. METHODS: Seventy-four subjects, including 38 patients with PD and 36 age-matched normal controls, participated in...
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