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HFE Genotype and Neurodegeneration: An Updated Systematic Review and Structured Evidence Synthesis with Four-Stratum Architecture

2026-03-16

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Common variants in the homeostatic iron regulator gene HFE, principally p.Cys282Tyr (C282Y; rs1800562) and p.His63Asp (H63D; rs1799945), alter systemic iron handling and may influence neurodegeneration through disrupted brain iron homeostasis. Prior meta-analyses produced heterogeneous effect estimates and did not systematically examine sex as an effect modif...

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Literature Corpus work
58d1e990-6ec3-5a77-a7f5-283eaa22d3b3
DOI
10.21203/rs.3.rs-9114391/v1
Open publication

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HFE Genotype and Neurodegeneration: An Updated Systematic Review and Structured Evidence Synthesis with Four-Stratum ArchitectureDOI 10.21203/rs.3.rs-9114391/v1
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