Article

Nigrosome-1 neuromelanin-iron coupling profiles in idiopathic and <i>GBA</i> -associated Parkinson’s disease

2025-11-04

Abstract excerpt

<h4>Background</h4> Firstly, to determine whether iron-sensitive MRI measures mediate neuromelanin (NM) loss within the substantia nigra pars compacta (SNc) and its subregion, nigrosome-1 (N1) in idiopathic Parkinson’s disease (iPD) and GBA -associated Parkinson’s disease (GBA-PD) versus healthy controls (HC). Secondly, to assess the diagnostic value of NM-and iron MRI metrics, including their lateralisation. <...

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Literature Corpus work: 37f34cc4-f67c-5401-bca0-6307c0a5b6d3
DOI: 10.1101/2025.11.03.25339328

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