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Article

HFE Mutations in Neurodegenerative Disease as a Model of Hormesis.

International journal of molecular sciences - 15 Mar 2024

Marshall Moscon Savannah L, Connor James R

Abstract excerpt

Common variants in the iron regulatory protein HFE contribute to systematically increased iron levels, yet the effects in the brain are not fully characterized. It is commonly believed that iron dysregulation is a key contributor to neurodegenerative disease due to iron's ability to catalyze reactive oxygen species production. However, whether HFE variants exacerbate or protect against neurodegeneration has been...

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PMID: 38542306
DOI: 10.3390/ijms25063334
PMCID: PMC10970347

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