Article

Glycolysis inhibition functionally reprograms T follicular helper cells and reverses lupus

2024-10-18

Abstract excerpt

<h4>Summary</h4> Systemic lupus erythematosus (SLE) is an autoimmune disease in which the production of pathogenic autoantibodies depends on T follicular helper (T FH ) cells. This study was designed to investigate the mechanisms by which inhibition of glycolysis with 2-deoxy-d-glucose (2DG) reduces the expansion of T FH cells and the associated autoantibody production in lupus-prone mice. Integrated cellular,...

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Literature Corpus work: cb5bd88b-a769-5b57-9491-0c354c3abda3
DOI: 10.1101/2024.10.15.618563

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