Article

Hematopoietic stem cells are a reservoir for trained immunity in autoimmune disease

2022-05-21

Abstract excerpt

<h4>SUMMARY</h4> Trained immunity (TI) has been speculated to serve as a contributor to autoimmune disease (AD) pathogenesis via generation of hyper-inflammatory myeloid cells. Using a mouse model of systemic lupus erythematosus (SLE), we show that hematopoietic stem cells (HSC) constitute a transplantable, long-term reservoir for macrophages that exhibit features of TI, including increased Mycobacterium avium k...

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Literature Corpus work: d9858ecf-a7f6-5960-9a13-6c58c0781a23
DOI: 10.1101/2022.05.20.492533

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