Article

Glutaminolysis promotes the function of follicular helper T cells in lupus-prone mice

2024-11-25

Abstract excerpt

Glutamine metabolism is essential for T cell activation and functions. The inhibition of glutaminolysis impairs Th17 cell differentiation and alters Th1 cell functions. There is evidence for an active glutaminolysis in the immune cells of lupus patients. Treatment of lupus-prone mice with glutaminolysis inhibitors ameliorated disease in association with a reduced frequency of Th17 cells. This study was performed t...

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Identifiers and source

Literature Corpus work: 2757e184-c484-50dd-a6d0-ac83051d2d90
DOI: 10.1101/2024.11.25.625088

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