Article

IRF7 controls spontaneous autoimmune germinal center and plasma cell checkpoints

2025-02-08

Abstract excerpt

How IRF7 promotes autoimmune B cell responses and systemic autoimmunity is unclear. Analysis of spontaneous SLE-prone mice deficient in IRF7 uncovered the IRF7 role in regulating autoimmune germinal center (GC), plasma cell (PC) and autoantibody responses and disease. IRF7, however, was dispensable for foreign antigen driven GC, PC and antibody responses. Competitive bone marrow (BM) chimeras highlighted the impor...

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Literature Corpus work: ad07cdf6-d903-544b-9957-ebb85dc8fd08
DOI: 10.1101/2025.02.04.636277

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