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Functional overlap of inborn errors of immunity and metabolism genes defines T cell metabolic vulnerabilities

16 Aug 2024

Abstract excerpt

Inborn errors of metabolism (IEMs) and immunity (IEIs) are Mendelian diseases in which complex phenotypes and patient rarity have limited clinical understanding. Whereas few genes have been annotated as contributing to both IEMs and IEIs, immunometabolic demands suggested greater functional overlap. Here, CRISPR screens tested IEM genes for immunologic roles and IEI genes for metabolic effects and found...

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PMID: 39151020
DOI: 10.1126/sciimmunol.adh0368

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