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Article

Functional differentiation and regulation of follicular T helper cells in inflammation and autoimmunity.

Immunology - 1 May 2021

Dong Lin, He Ying, Cao Yejin, Wang Yuexin, Jia Anna, Wang Yufei, Yang Qiuli, Li Wanjie, Bi Yujing, Liu Guangwei

Abstract excerpt

Follicular T helper (TFH ) cells are specialized T cells that support B cells, which are essential for humoral immunity. TFH cells express the transcription factor B-cell lymphoma 6 (Bcl-6), chemokine (C-X-C motif) receptor (CXCR) 5, the surface receptors programmed cell death protein 1 (PD-1) and inducible T-cell costimulator (ICOS), the cytokine IL-21 and other molecules. The activation, proliferation and...

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Identifiers

PMID: 33128768
DOI: 10.1111/imm.13282
PMCID: PMC8044332

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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