Characterization of the metabolic phenotype of chronically activated lymphocytes.

doi:10.1177/0961203310373109

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Article

Characterization of the metabolic phenotype of chronically activated lymphocytes.

Lupus - 1 Nov 2010

Wahl D R, Petersen B, Warner R, Richardson B C, Glick G D, Opipari A W

Abstract excerpt

Activated lymphocytes proliferate, secrete cytokines, and can make antibodies. Normally activated B and T cells meet the bioenergetic demand for these processes by up-regulating aerobic glycolysis. In contrast, several lines of evidence suggest that pathogenic lymphocytes in autoimmune diseases like lupus meet ATP demands through oxidative phosphorylation. Using (13)C-glucose as a stable tracer, we found that...

Topics

Adenosine Triphosphate
Animals
Antigens
Cells, Cultured
Female
Glucose
Glycolysis
Humans
Lactic Acid
Lupus Erythematosus, Systemic
Lymphocyte Activation
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred BALB C

Mice, Inbred NZB

Oxidation-Reduction

Phenotype

Spleen

T-Lymphocytes

Source

Open in PubMed

Identifiers

PMID: 20647250
DOI: 10.1177/0961203310373109

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