Article
Normalization of CD4+ T cell metabolism reverses lupus.
Science translational medicine - 11 Feb 2015
Yin Yiming, Choi Seung-Chul, Xu Zhiwei, Perry Daniel J, Seay Howard, Croker Byron P, Sobel Eric S, Brusko Todd M, Morel Laurence
Abstract excerpt
Systemic lupus erythematosus (SLE) is an autoimmune disease in which autoreactive CD4(+) T cells play an essential role. CD4(+) T cells rely on glycolysis for inflammatory effector functions, but recent studies have shown that mitochondrial metabolism supports their chronic activation. How these processes contribute to lupus is unclear. We show that both glycolysis and mitochondrial oxidative metabolism are...
Topics
- Animals
- CD4-Positive T-Lymphocytes
- Deoxyglucose
- Disease Models, Animal
- Lupus Erythematosus, Systemic
- Metformin
- Mice
- Phenotype