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Article

SCONCE2: jointly inferring single cell copy number profiles and tumor evolutionary distances.

BMC bioinformatics - 19 Aug 2022

Hui Sandra, Nielsen Rasmus

Abstract excerpt

BACKGROUND: Single cell whole genome tumor sequencing can yield novel insights into the evolutionary history of somatic copy number alterations. Existing single cell copy number calling methods do not explicitly model the shared evolutionary process of multiple cells, and generally analyze cells independently. Additionally, existing methods for estimating tumor cell phylogenies using copy number profiles are...

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PMID: 35986254
DOI: 10.1186/s12859-022-04890-w
PMCID: PMC9392257

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