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Article

Integrative pipeline for profiling DNA copy number and inferring tumor phylogeny.

Bioinformatics (Oxford, England) - 15 Jun 2018

Urrutia Eugene, Chen Hao, Zhou Zilu, Zhang Nancy R, Jiang Yuchao

Abstract excerpt

Summary: Copy number variation is an important and abundant source of variation in the human genome, which has been associated with a number of diseases, especially cancer. Massively parallel next-generation sequencing allows copy number profiling with fine resolution. Such efforts, however, have met with mixed successes, with setbacks arising partly from the lack of reliable analytical methods to meet the...

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PMID: 29415173
DOI: 10.1093/bioinformatics/bty057
PMCID: PMC6248831

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