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Pharming: Joint Clonal Tree Reconstruction of Single-Nucleotide Variant and Copy Number Aberration Evolution from Single-Cell DNA Sequencing of Tumors.

Journal of computational biology : a journal of computational molecular cell biology - 1 Jan 2026

Weber Leah L, Hart Anna, Ochoa Idoia, El-Kebir Mohammed

Abstract excerpt

Cancer arises through an evolutionary process in which somatic mutations, including single-nucleotide variants (SNVs) and copy number aberrations (CNAs), drive the development of a malignant, heterogeneous tumor. Reconstructing this evolutionary history from sequencing data is critical for understanding the order in which mutations are acquired and the dynamic interplay between different types of alterations....

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PMID: 40944534
DOI: 10.1177/15578666251374694

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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Pharming: Joint Clonal Tree Reconstruction of Single-Nucleotide Variant and Copy Number Aberration Evolution from Single-Cell DNA Sequencing of Tumors.PMID 40944534Read ↗

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