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CONET: copy number event tree model of evolutionary tumor history for single-cell data

9 Jun 2022

Abstract excerpt

Copy number alterations constitute important phenomena in tumor evolution. Whole genome single-cell sequencing gives insight into copy number profiles of individual cells, but is highly noisy. Here, we propose CONET, a probabilistic model for joint inference of the evolutionary tree on copy number events and copy number calling. CONET employs an efficient, regularized MCMC procedure to search the space of...

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PMID: 35681161
DOI: 10.1186/s13059-022-02693-z

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