Article

Deep learning the cis-regulatory code of chromatin dynamics during cellular reprogramming

2023-10-04

Abstract excerpt

The concentration and stoichiometry of transcription factors (TFs) determine cellular identity and can be manipulated to drive cell state transitions. Understanding how changes in TF concentration regulate chromatin state and expression across cell state transitions remains a challenge. We investigated this relationship by profiling chromatin accessibility and gene expression at single-cell resolution across a den...

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Literature Corpus work: cade8a60-66ca-5cbd-8ddc-77c58a0b2bfb
DOI: 10.1101/2023.10.04.560808

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