Article

DoseH-seq: A single-cell multiome platform to decode gene-dosage logic driving developmental reversion and cell fate reprogramming

2025-12-23

Abstract excerpt

<title>Abstract</title> <p>Cell identity is governed by graded transcription factor (TF) activity, yet current single-cell tools do not resolve how TF dosage shapes both gene expression and chromatin accessibility. We present DoseH-seq, a dosage-resolved single-nucleus RNA+ATAC multiome assay built on standard 10x Genomics workflows. DoseH-seq integrates sample hashing with quantitative tracking of continuous len...

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Literature Corpus work: 979b8bc0-e8be-5056-85ff-24e58d863118
DOI: 10.21203/rs.3.rs-8400524/v1

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