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Article

Epigenomic states contribute to coordinated allelic transcriptional bursting in iPSC reprogramming.

Life science alliance - 1 Apr 2024

Ayyamperumal Parichitran, Naik Hemant Chandru, Naskar Amlan Jyoti, Bammidi Lakshmi Sowjanya, Gayen Srimonta

Abstract excerpt

Two alleles of a gene can be transcribed independently or coordinatedly, which can lead to temporal expression heterogeneity with potentially distinct impacts on cell fate. Here, we profiled genome-wide allelic transcriptional burst kinetics during the reprogramming of MEF to induced pluripotent stem cells. We show that the degree of coordination of allelic bursting differs among genes, and alleles of many...

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Identifiers

PMID: 38320809
DOI: 10.26508/lsa.202302337
PMCID: PMC10847334

Genes

BRD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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