Article

Transcription factors orchestrate dynamic interplay between genome topology and gene regulation during cell reprogramming

2017-04-30

Abstract excerpt

<h4>ABSTRACT</h4> Chromosomal architecture is known to influence gene expression, yet its role in controlling cell fate remains poorly understood. Reprogramming of somatic cells into pluripotent stem cells by the transcription factors (TFs) Oct4, Sox2, Klf4 and Myc offers an opportunity to address this question but is severely limited by the low proportion of responding cells. We recently developed a highly effic...

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Literature Corpus work: b313c11a-e443-567a-a847-b9febf119e94
DOI: 10.1101/132456

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