Article

Evolutionary transfer learning enables organism-wide inference of mammalian enhancer landscapes

2026-04-08

Abstract excerpt

<h4>ABSTRACT</h4> Understanding and modeling how a single human genome concurrently encodes gene regulatory programs for thousands of cell types remains a central challenge in genomics and machine learning. Most human cell types emerge during embryonic, fetal, and pediatric development which are inaccessible to comprehensive molecular profiling. To circumvent this, we hypothesized that the mismatch in evolutionar...

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Literature Corpus work: 98a5c812-2726-5da1-bff0-034865718eb7
DOI: 10.64898/2026.04.07.717039

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