Article

scRegulate: Single-Cell Regulatory-Embedded Variational Inference of Transcription Factor Activity from Gene Expression

2025-04-22

Abstract excerpt

<h4>Motivation</h4> Accurately inferring transcription factor (TF) activity from single-cell RNA sequencing (scRNA-seq) data remains a fundamental challenge in computational biology. While existing methods rely on statistical models, motif enrichment, or prior-based inference, they often depend on deterministic assumptions about regulatory relationships and rely on static regulatory databases. Few approaches effe...

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Literature Corpus work: 3cb459f4-230c-59c9-86e3-2d3f45fdbe45
DOI: 10.1101/2025.04.17.649372

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