Article

scDirect: key transcription factor identification for directing cell state transitions based on single-cell multi-omics data

2024-01-09

Abstract excerpt

Cell state transitions are complicated processes that occur in various life activities. Understanding and artificially manipulating them have been longstanding challenges. Substantial experiments reveal that the transitions could be directed by several key transcription factors (TFs). Here we present scDirect, a computational framework to identify key TFs based on single-cell RNA-seq and ATAC-seq data. scDirect mo...

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Literature Corpus work: bdd92723-8a86-53bd-bd39-5fa2a84c517f
DOI: 10.1101/2024.01.08.574757

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