Article

<i>APOE4</i> genotype negates the benefits of 17β-estradiol on cerebrovascular endothelial and mitochondrial function

2025-07-29

Abstract excerpt

<h4>Background</h4> Postmenopausal females who carry an APOEε4 allele are at higher risk of late-onset Alzheimer’s Disease compared to age-matched APOEε4 males. Estrogen deficiency predisposes females to an increased risk of vascular, cognitive, and metabolic impairments. While estrogen and APOE genotype are known to impact metabolic and mitochondrial function in the brain, their cerebrovascular effects are le...

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Literature Corpus work: caa4ca3a-181c-5726-94ab-7eff183e85b9
DOI: 10.1101/2025.07.23.666474

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