Article

<i>APOE4</i> is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged <i>APOE</i> Mice

2018-11-29

Abstract excerpt

<h4>ABSTRACT</h4> The ε4 allele of apolipoprotein E ( APOE ) is the dominant genetic risk factor for late-onset Alzheimer’s disease (AD). However, the reason for the association between APOE4 and AD remains unclear. While much of the research has focused on the ability of the apoE4 protein to increase the aggregation and decrease the clearance of Aβ, there is also an abundance of data showing that APOE4 negati...

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Literature Corpus work: f972037c-9c61-5a37-be08-4bddcdde7716
DOI: 10.1101/482422

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