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Protection against <i>APOE4</i> -associated aging phenotypes with the longevity-promoting intervention 17α-estradiol in male mice

2024-03-14

Abstract excerpt

<h4>Summary</h4> The apolipoprotein ε4 allele ( APOE4 ) is associated with decreased longevity, increased vulnerability to age-related declines, and disorders across multiple systems. Interventions that promote healthspan and lifespan represent a promising strategy to attenuate the development of APOE4 -associated aging phenotypes. Here we studied the ability of the longevity-promoting intervention 17α-estradio...

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Literature Corpus work
38adb1af-a44e-5a66-a486-11eaf860b7c0
DOI
10.1101/2024.03.12.584678
Open publication

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Protection against <i>APOE4</i> -associated aging phenotypes with the longevity-promoting intervention 17α-estradiol in male miceDOI 10.1101/2024.03.12.584678
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