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Article

17α-Estradiol Confers Limited Protection Against <i>APOE4</i> Phenotypes in Middle-Aged Female Mice

2026-08-07

Abstract excerpt

<h4>Summary</h4> Longevity-promoting interventions represent a promising strategy to mitigate brain aging and reduce Alzheimer’s disease (AD) risk. The NIA Interventions Testing Program identified the weak estrogen 17α-estradiol (17αE2) as a compound that extends healthspan and lifespan in mice, with effects observed primarily in males. Our recent work demonstrated that 17αE2 healthspan benefits were modulated by...

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Literature Corpus work
77d2cb4c-207d-5fa9-87ca-47b4810c6482
DOI
10.64898/2026.08.06.743074
Open publication

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17α-Estradiol Confers Limited Protection Against <i>APOE4</i> Phenotypes in Middle-Aged Female MiceDOI 10.64898/2026.08.06.743074
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