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Effects of obesogenic diet and 17β-estradiol in female mice with APOE 3/3, 3/4, and 4/4 genotypes

13 Sept 2024

Abstract excerpt

The main genetic risk factor for Alzheimer’s disease (AD) is the apolipoprotein E ε4 allele ( APOE4 ). AD risk associated with APOE4 disproportionately affects women. Furthermore, human and rodent studies indicate that the cognitive deficits associated with APOE4 are greater in females. One modifiable AD risk factor is obesity during middle age. Given that approximately two-thirds of US adults are overweight, it...

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PMID: 39347015
DOI: 10.3389/fnagi.2024.1415072

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