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Article

Impacts of APOE-ε4 and exercise training on brain microvascular endothelial cell barrier function and metabolism.

EBioMedicine - 1 Jan 2025

Weber Callie M, Moiz Bilal, Pena Gabriel S, Kheradmand Marzyeh, Wunderler Brooke, Kettula Claire, Sangha Gurneet S, Smith J Carson, Clyne Alisa Morss

Abstract excerpt

BACKGROUND: The APOE-ε4 genotype is the highest genetic risk factor for Alzheimer's disease (AD), and exercise training can reduce the risk of AD. Two early pathologies of AD are degradation of tight junctions between brain microvascular endothelial cells (BMEC) and brain glucose hypometabolism. Therefore, the objective of this work was to determine how the APOE-ε4 genotype and serum from exercise trained...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39647262
DOI: 10.1016/j.ebiom.2024.105487
PMCID: PMC11667009

Genes

APOE
SIRT1
NSF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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