Article

Mutational signatures of complex genomic rearrangements in human cancer

2021-05-17

Abstract excerpt

Complex genomic rearrangements (CGRs) are common in cancer and are known to form via two aberrant cellular structures—micronuclei and chromatin bridge. However, which mechanism is more relevant to CGR formation in cancer cells and whether there are other undiscovered mechanisms remain open questions. Here, we analyze 2,014 CGRs from 2,428 whole-genome sequenced tumors and deconvolute six CGR signatures based on th...

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Literature Corpus work: 8d563647-7875-5953-bcdf-aa2a6c389980
DOI: 10.1101/2021.05.16.444385

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