Article

Mutational signatures of complex genomic rearrangements in human cancer

2021-05-25

Abstract excerpt

<title>Abstract</title> <p>Complex genomic rearrangements (CGRs) are common in cancer and are known to form via two aberrant cellular structures—micronuclei and chromatin bridge. However, which mechanism is more relevant to CGR formation in cancer cells and whether there are other undiscovered mechanisms remain open questions. Here, we analyze 2,014 CGRs from 2,428 whole-genome sequenced tumors and deconvolute si...

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Literature Corpus work: 5fa6bab8-6433-57c9-91c5-391e8ea5ad9a
DOI: 10.21203/rs.3.rs-535468/v1

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