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MLL family members regulate H3K4 methylation to ensure CENP-A assembly at human centromeres

2022-06-20

Abstract excerpt

The active state of centromeres is epigenetically defined by the presence of CENP-A interspersed with histone H3 nucleosomes. While the importance of dimethylation of H3K4 mark for centromeric transcription has been highlighted in various studies, the identity of the enzyme(s) depositing these marks on the centromere is still unknown. The MLL (KMT2) family play a crucial role in RNA polymerase II (Pol II)-mediated...

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Literature Corpus work
c94d93d7-45d7-5ebd-924a-c0edbf3cc2ad
DOI
10.1101/2022.06.20.496844
Open publication

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MLL family members regulate H3K4 methylation to ensure CENP-A assembly at human centromeresDOI 10.1101/2022.06.20.496844
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