Article

CDCA7 facilitates MET1-mediated CG DNA methylation maintenance in centromeric heterochromatin via histone H1

2025-09-22

Abstract excerpt

DNA methylation is a conserved epigenetic modification essential for maintaining genome stability. However, how methyltransferases maintain CG methylation within compact chromatin, including centromeres, remains unclear. In humans, CDCA7 is necessary for the inheritance of DNA methylation at juxta-centromeres. Mutations that impair its ability to bind chromatin result in Immunodeficiency, Centromeric Instability,...

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Literature Corpus work: b41bbd7c-d763-5b3d-aeb4-a58f3248c1a8
DOI: 10.1101/2025.09.22.677529

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