Article

The ratio between centromeric proteins CENP-A and CENP-C maintains homeostasis of human centromeres

2019-04-10

Abstract excerpt

The centromere is the chromosomal locus that seeds the kinetochore, allowing for a physical connection between the chromosome and the mitotic spindle. At the heart of the centromere is the centromere-specific histone H3 variant CENP-A/CENH3. Throughout the cell cycle the constitutive centromere associated network is bound to CENP-A chromatin, but how this protein network modifies CENP-A nucleosome dynamics in viv...

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Literature Corpus work: 084b065f-4007-588d-bbd4-f17853ae9411
DOI: 10.1101/604223

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