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Assembly principles and stoichiometry of a complete human kinetochore module

2020-12-02

Abstract excerpt

Centromeres are epigenetically determined chromosomal loci that seed kinetochore assembly to promote chromosome segregation during cell division. CENP-A, a centromere-specific histone H3 variant, establishes the foundations for centromere epigenetic memory and kinetochore assembly. It recruits the constitutive centromere-associated network (CCAN), which in turn assembles the microtubule-binding interface. How the...

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Identifiers and source

Literature Corpus work
741d9374-69fb-5ecb-aba8-489f15a1a192
DOI
10.1101/2020.12.01.407130
Open publication

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Assembly principles and stoichiometry of a complete human kinetochore moduleDOI 10.1101/2020.12.01.407130
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