Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation of cancer driver MLL2 results in transcription stress and genome instability.

Genes & development - 15 Feb 2016

Kantidakis Theodoros, Saponaro Marco, Mitter Richard, Horswell Stuart, Kranz Andrea, Boeing Stefan, Aygün Ozan, Kelly Gavin P, Matthews Nik, Stewart Aengus, Stewart A Francis, Svejstrup Jesper Q

Abstract excerpt

Genome instability is a recurring feature of tumorigenesis. Mutation in MLL2, encoding a histone methyltransferase, is a driver in numerous different cancer types, but the mechanism is unclear. Here, we present evidence that MLL2 mutation results in genome instability. Mouse cells in which MLL2 gene deletion can be induced display elevated levels of sister chromatid exchange, gross chromosomal aberrations, 53BP1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to DNA Damage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genomic Instability

Share to Histone-Lysine N-Methyltransferase

Share to Myeloid-Lymphoid Leukemia Protein

Share to RecQ Helicases

Share to RNA Polymerase II

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 26883360
DOI: 10.1101/gad.275453.115
PMCID: PMC4762426

Genes

RECQL5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation of cancer driver MLL2 results in transcription stress and genome instability.PMID 26883360Read ↗

Genomic Instability and CancerSemantic proximity Read ↗

The lysine‐specific methyltransferase KMT2C/MLL3 regulates DNA repair components in cancerSemantic proximity Read ↗

Global identification of MLL2-targeted loci reveals MLL2’s role in diverse signaling pathwaysSemantic proximity Read ↗

KMT2C-deficient tumors have elevated APOBEC mutagenesis and genomic instability in multiple cancersSemantic proximity Read ↗

Recruitment of KMT2C/MLL3 to DNA Damage Sites Mediates DNA Damage Responses and Regulates PARP Inhibitor Sensitivity in Cancer.Semantic proximity Read ↗

Loss of RMI2 Increases Genome Instability and Causes a Bloom-Like Syndrome.Semantic proximity Read ↗

SETting the Stage for Cancer Development: SETD2 and the Consequences of Lost Methylation.Semantic proximity Read ↗

Ubiquitin E3 ligases in cancer: somatic mutation and amplificationSemantic proximity Read ↗

Molecular mechanisms of KMT2C alterations in gastrointestinal cancers: enhancer network destabilization, lineage plasticity, and clinical translation.Semantic proximity Read ↗

Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia.Semantic proximity Read ↗

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer.Semantic proximity Read ↗

MLL3 regulates the <i>CDKN2A</i> tumor suppressor locus in liver cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.