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Article

Histone H3 lysine 4 methyltransferase KMT2D.

Gene - 5 Sept 2017

Froimchuk Eugene, Jang Younghoon, Ge Kai

Abstract excerpt

Histone-lysine N-methyltransferase 2D (KMT2D), also known as MLL4 and MLL2 in humans and Mll4 in mice, belongs to a family of mammalian histone H3 lysine 4 (H3K4) methyltransferases. It is a large protein over 5500 amino acids in size and is partially functionally redundant with KMT2C. KMT2D is widely expressed in adult tissues and is essential for early embryonic development. The C-terminal SET domain is...

Topics

Animals
Histone-Lysine N-Methyltransferase
Histones
Humans
Mutation
Neoplasms

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 28669924
DOI: 10.1016/j.gene.2017.06.056
PMCID: PMC5546304

Genes

NCOA6
SET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-28669924-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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