Article

Living cell mTORC1 inhibition reporter mTIR reveals nutrient-sensing targets of histone deacetylase inhibitor

2023-05-19

Abstract excerpt

<h4>SUMMARY</h4> Mammalian or mechanistic target of rapamycin complex 1 (mTORC1) is a clinically effective therapeutic target for diseases such as cancer, diabetes, aging, and neurodegeneration, yet an efficient tool to monitor mTORC1 inhibition in living cells or tissues is still lacking. Here we devised a genetically encoded mTORC1 inhibition reporter termed mTIR that exhibits a highly contrasted fluorescence p...

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Literature Corpus work: c8b9cffb-a976-5135-8ae4-f1eb1cc3fafa
DOI: 10.1101/2023.05.19.541400

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