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Article

Real-time imaging of histone H4 hyperacetylation in living cells.

Proceedings of the National Academy of Sciences of the United States of America - 22 Sept 2009

Sasaki Kazuki, Ito Tamaki, Nishino Norikazu, Khochbin Saadi, Yoshida Minoru

Abstract excerpt

To visualize histone acetylation in living cells, we developed a genetically encoded fluorescent resonance energy transfer (FRET)-based indicator. Response of the indicator reflects changes in the acetylation state of both K5 and K8 in histone H4. Using this acetylation indicator, we were able to monitor the dynamic fluctuation of histone H4 acetylation levels during mitosis, as well as acetylation changes in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19805290
DOI: 10.1073/pnas.0902150106
PMCID: PMC2752582

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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