Article

The CTLH Ubiquitin Ligase Substrates ZMYND19 and MKLN1 Negatively Regulate mTORC1 at the Lysosomal Membrane

2024-04-24

Abstract excerpt

<title>Abstract</title> <p>Most Epstein–Barr virus-associated gastric carcinoma (EBVaGC) harbor non-silent mutations that activate phosphoinositide 3 kinase (PI3K) to drive downstream metabolic signaling. To gain insights into PI3K/mTOR pathway dysregulation in this context, we performed a human genome-wide CRISPR/Cas9 screen for hits that synergistically blocked EBVaGC proliferation together with the PI3K antago...

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Literature Corpus work: fa5c0e0e-8544-5902-882a-06760bde8b55
DOI: 10.21203/rs.3.rs-4259395/v1

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