Article

Integrated proteasomal and lysosomal activity shape mTOR-regulated proteome remodeling

2024-07-20

Abstract excerpt

<h4>ABSTRACT</h4> The crucial growth regulator mTOR is suppressed during nutrient limitation, which reduces protein synthesis and activates the ubiquitin-proteasome system (UPS) and lysosomal degradation pathways. Whereas these pathways have been extensively studied individually, their integrated dynamics, including the interplay between protein synthesis and degradation, and the coordination between lysosomal an...

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Literature Corpus work: 70a8c12d-ecdb-54e3-a1d6-f27a56ac7ba0
DOI: 10.1101/2024.07.20.603815

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