Back to search

Article

A novel pH-sensitive probe to quantify autophagy on high throughput/content imaging platforms

2025-05-14

Abstract excerpt

Autophagy is a highly-conserved mechanism that ensures the lysosomal degradation of disposable or potential toxic cytosolic entities in support of cell survival and adaptation to stress. Autophagy is deregulated in various pathological conditions including cardiovascular, neurological, neoplastic-autoimmune and degenerative disorders. However, clinically relevant pharmacological modulators of autophagy remain elus...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
37179db2-cebc-5599-ad7e-4f8c1f7501c8
DOI
10.1101/2025.05.13.653902
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A novel pH-sensitive probe to quantify autophagy on high throughput/content imaging platformsDOI 10.1101/2025.05.13.653902
De novo design of a novel AIE fluorescent probe tailored to autophagy visualization via pH manipulationSemantic proximity
Quantitative profiling of lysosomal accumulation through label-free biomarkers via High-Content Holo-Tomographic Flow CytometrySemantic proximity
Lysosomal Profiling with LysoTracker for Quantitative Assessment of Cellular Senescence in Human FibroblastsSemantic proximity
pHLARE: A Genetically Encoded Ratiometric Lysosome pH BiosensorSemantic proximity
Small fluorescent molecules for monitoring autophagic fluxSemantic proximity
Fullerenols hijack lysosomes to disrupt inter-organellar crosstalk and block autophagy pre-activated by mTOR inhibitors for cancer cell PANoptosisSemantic proximity
Reimagining dots and dashes: Visualizing structure and function of organelles for high-content imaging analysis.Semantic proximity
Establishment of a novel fluorescence-based method to evaluate chaperone-mediated autophagy in a single neuron.Semantic proximity
The dynamics of autophagy visualized in live cells: from autophagosome formation to fusion with endo/lysosomes.Semantic proximity
A novel method for autophagy detection in primary cellsSemantic proximity
Living cell mTORC1 inhibition reporter mTIR reveals nutrient-sensing targets of histone deacetylase inhibitorSemantic proximity
Modulation of autophagic activity by extracellular pHSemantic proximity
Select a neighboring publication to make it the new centre.