Article

Metabolic STAMP reveals GPCR signaling networks that program β-cell insulin secretion

2025-10-04

Abstract excerpt

<h4>SUMMARY</h4> Pancreatic islet β cells integrate glucose and hormonal cues to control insulin secretion through spatially and temporally organized phosphorylation networks in health and diabetes. Here, using Metabolic STAMP (Synchronized Temporal-Spatial Analysis via Microscopy and Phosphoproteomics), we combine time-resolved phosphoproteomics, imaging, and kinase inhibition in mouse β cells and human islets t...

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Literature Corpus work: 28a637cf-a849-5743-864d-aca7f16a832e
DOI: 10.1101/2025.10.03.680349

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